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2022
2020
2019
--- Joined McMaster University ---
2017
2022
- Wang, Y.; Singer, R.; Liu, X.; Inman, S. J.; Cao, Q.; Zhou, Q.; Noble, A.; Li, L.; Ask, K.; Kolb, M. R.; Ramsay, S.; Geng, F.; Zhang, B.; Shargail, Y.; Moran-Mirabal, J.; Dabaghi, M.; Hirota, J. A., The CaT Stretcher: An Open-Source System for Delivering Uniaxial Strain to Cells and Tissues (CaT). Frontiers in Bioengineering and Biotechnology. 2022. Link to paper
- Deering, J.; Lin, D. S. Y.; D'Elia, A.; Zhang, B.; Grandfield, K., Fabrication of succinate-alginate xerogel films for in vitro coupling of osteogenesis and neovascularization. Biomaterials Advances 2022, 141, 213122. Link to paper
- Abdul, L.; Xu, J.; Sotra, A.; Chaudary, A.; Gao, J.; Rajasekar, S.; Anvari, N.; Mahyar, H.; Zhang, B., D-CryptO: deep learning-based analysis of colon organoid morphology from brightfield images. Lab on a Chip 2022. Link to paper; Link to preprint
- Asadi Jozani, K.; Kouthouridis, S.; Hirota, J. A.; Zhang, B., Next generation preclinical models of lung development, physiology and disease. The Canadian Journal of Chemical Engineering. 2022. Link to paper
- Kouthouridis, S.; Robson, E.; Hartung, A.; Raha, S.; Zhang, B., Se(XY) matters: the importance of incorporating sex in microphysiological models. Trends in Biotechnology 2022. Link to paper
- Rajasekar, S.; Lin, D. S. Y.; Zhang, F.; Sotra, A.; Boshart, A.; Clotet-Freixas, S.; Liu, A.; Hirota, J. A.; Ogawa, S.; Konvalinka, A.; Zhang, B., Subtractive manufacturing with swelling induced stochastic folding of sacrificial materials for fabricating complex perfusable tissues in multi-well plates. Lab on a Chip 2022. Link to paper
- Sotra, A.; Zhang, B., Seeding A Growing Organ. Trends in Biotechnology 2021. Link to paper
- Lai, B. F. L.; Lu, R. X. Z.; Davenport Huyer, L.; Kakinoki, S.; Yazbeck, J.; Wang, E. Y.; Wu, Q.; Zhang, B.; Radisic, M., A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature. Nature Protocols 2021. Link to paper
- Dabaghi, M.; Saraei, N.; Carpio, M. B.; Nanduri, V.; Ungureanu, J.; Babi, M.; Chandiramohan, A.; Noble, A.; Revill, S. D.; Zhang, B.; Ask, K.; Kolb, M.; Shargall, Y.; Moran-Mirabal, J.; Hirota, J. A., A Robust Protocol for Decellularized Human Lung Bioink Generation Amenable to 2D and 3D Lung Cell Culture. Cells 2021, 10 (6), 1538. Link
- Portillo Esquivel, L. E.; Zhang, B., Application of Cell, Tissue, and Biomaterial Delivery in Cardiac Regenerative Therapy. ACS Biomaterials Science & Engineering 2021. Link to paper
2020
- Hayward, K.; Kouthouridis, S.; Zhang, B., Organ-on-a-chip systems for modelling pathological tissue morphogenesis associated with fibrosis and cancer. ACS Biomaterials Science and Engineering 2020. Link to paper
- Abdul, L.; Rajasekar, S.; S.Y. Lin, D.; Venkatasubramania Raja, S.; Sotra, A.; Feng, Y.; Liu, A.; Zhang, B., Deep-LUMEN Assay – Human lung epithelial spheroid classification from brightfield images using deep learning. Lab on a Chip 2020. View preprint; Link to preprint; Link to paper
- Rajasekar, S.; Lin, D.S.Y; Abdul, L., Liu, A., Sotra, A., Zhang, F., Zhang, B., IFlowPlate - A customized 384-well plate for the culture of perusable vascularized colon organoids. Advanced Materials 2020. View preprint; Link to paper
- Lin, D. S. Y.; Rajasekar, S.; Marway, M. K.; Zhang, B., From Model System to Therapy: Scalable Production of Perfusable Vascularized Liver Spheroids in “Open-Top“ 384-Well Plate. ACS Biomaterials Science & Engineering 2020. View preprint; Link to Paper
- Portillo-Esquivel, L. E.; Nanduri, V.; Zhang, F.; Liang, W.; Zhang, B., z-Wire: A Microscaffold That Supports Guided Tissue Assembly and Intramyocardium Delivery for Cardiac Repair. Advanced Healthcare Materials 2020, 2000358. View View Preprint; Video S1; Video S2; Video S3; Video S4; Video S5; Video S6; Video S7; Video S8. Link to Paper.
- Xie, R.; Korolj, A.; Liu, C.; Song, X.; Lu, R. X. Z.; Zhang, B.; Ramachandran, A.; Liang, Q.; Radisic, M., h-FIBER: Microfluidic Topographical Hollow Fiber for Studies of Glomerular Filtration Barrier. ACS Central Science 2020. View PDF,
2019
- Zhang, B.; Radisic, M., Organ-level vascularization: The Mars Mission of Bioengineering. The Journal of Thoracic and Cardiovascular Surgery 2019. View PDF
- Parrish, J.; Lim, K.; Zhang, B.; Radisic, M.; Woodfield, T. B. F., New Frontiers for Biofabrication and Bioreactor Design in Microphysiological System Development. Trends in Biotechnology, 2019. View PDF
- Yimu Zhao.; Wang, E.Y.; Huyer, L.D.; Liao, S.; Yeager, K; Vunjak-Novakovic, G.; Radisic, M.; Boyang Zhang, A multimaterial microphysiological platform enabled by rapid casting of elastic micro-wires. Advanced Healthcare Materials, 2019. View PDF
- Yimu Zhao, Naimeh Rafatian, Nicole T. Feric, Brian J. Cox, Roozbeh Aschar-Sobbi, Erika Yan Wang, Praful Aggarwal, Boyang Zhang, Genevieve Conant, Kacey Ronaldson-Bouchard, Aric Pahnke, Stephanie Protze, Jee Hoon Lee, Locke Davenport Huyer, Danica Jekic, Anastasia Wickeler, Hani E. Naguib, Gordon M. Keller, Gordana Vunjak-Novakovic, Ulrich Broeckel, Peter H. Backx, Milica Radisic, A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling, Cell, 2019. View PDF
- Dawn S. Y. Lin, Feng Guo, Boyang Zhang, Modeling organ-specific vasculature with organ-on-a-chip devices, Nanotechnology, 2018. View PDF
- Anastasia Korolj, Carol Laschinger, Chris James, Erding Hu, Claire Velikonja, Nathaniel Smith, Irene Gu, Samad Ahadian, Robert Willette, Milica Radisic and Boyang Zhang, Curvature facilitates podocyte culture in a biomimetic platform, Lab on a Chip, 2018. View PDF
- Boyang Zhang , Benjamin Fook Lun Lai, Ruoxiao Xie, Locke Davenport Huyer, Miles Montgomery, Milica Radisic, Microfabrication of AngioChip, a biodegradable polymer scaffold with microfluidic vasculature, Nature Protocol, 2018. View PDF
- Boyang Zhang, Anastasia Korolj, Benjamin Fook Lun Lai, Milica Radisic, Advances in organ-on-a-chip engineering. Nature Reviews Materials, 2018. View PDF
--- Joined McMaster University ---
2017
- Kacey Ronaldson, Nicole Feric, Yimu Zhao, Boyang Zhang , Genna Conant, Aric Panhke, Roozbeh Aschar-Sobbi, Gordana Vunjak-Novakovic, Peter Backx, Milica Radisic, TARA Biosystems' BiowireTM II: Engineering Mature Human Cardiac Tissues Enables More Predictive Drug Screening, Journal of Pharmacological and Toxicological Methods, 2017. View PDF
- Takebe T., Zhang B., Radisic M., Synergistic Engineering: Organoids meets Organs-on-a-Chip, Cell Stem Cell, 2017. View PDF
- Lai B., Davenport L., Lu R., Drecun S., Radisic M., Zhang B., InVADE: Integrated Vasculature for Assessing Dynamic Events. Advanced Functional Materials, 2017. View PDF
- Ahadian S., Civitarese R., Bannerman D., Mohammadi M., Rick L., Wang Y., Huyer L., Lai F., Zhang B., Zhao Y., Mandla S., Korolj A., Radisic, M., Organ-on-a-chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies, Advanced Healthcare Materials, 2017. View PDF
- Zhang B., Radisic M., Organ-on-a-Chip devices advance to market. Lab on a Chip, 2017. View PDF
- Massé S., Magtibay K., Jackson N., Asta J., Kusha M., Zhang B., Balachandran R, Radisic M., Deno D. C., and Nanthakumar K. Resolving myocardial activation with novel omnipolar electrograms. Circulation – Arrhythmia and Electrophysiology. 2016. View PDF
- Davenport Huyer L, Zhang B, Korolj A, Montgomery M, Drecun S, Conant G, Zhao Y, Reis L, Radisic M. A highly elastic and moldable polyester biomaterial for cardiac tissue engineering applications. ACS Biomaterials Science & Engineering. 2016. View PDF
- Zhang B, Montgomery M, Chamberlain M.D., Ogawa S., Korolj, A., Pahnke A, Wells L.A., Massé S, Kim J, Reis L, Abdulah M, Nunes S.S., Nanthakumar K, Gordon, K., Sefton M.V., Radisic M. Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis. Nature Materials (Featured on the cover). 2016. View PDF, Supplementary Doc, Movie S1, Movie S2, Movie S3, Movie S4, Movie S5, Movie S6, Movie S7.
- "AngioChip" highlighted in:
- Nature Reviews Materials, "Tissue engineering: A hearty chip", 2016. View PDF
- Toronto Star, "U of T researchers develop homegrown human on a chip", 2016.
- CBC The National, "Beating 'heart on a chip' developed by Canadian scientists", 2016.
- Yahoo News, "3-D heart, liver tissues that function like real organs grown", 2016.
- "AngioChip" highlighted in:
- Zhang B, Montgomery M, L Davenport-Huyer, A Korolj, Radisic M. Platform technology for scalable assembly of instantaneously functional mosaic tissues. Science Advances. 2015; 1 (7), e1500423. View PDF
- "Tissue Velcro" highlighted in:
- Popular Science, "Synthetic Heart Tissue Sticks Like Velcro", 2015.
- MotherBoard Vice, "This Lab-Grown Tissue Snaps Together Like Velcro", 2015.
- New Scientist, "Live cells stuck together like Velcro could mend broken hearts", 2015.
- The Scientist, "Next Generation: Cell-Covered Fastener", 2015.
- "Tissue Velcro" highlighted in:
- Montgomery M, Zhang B (co-first author), Radisic M. Cardiac Tissue Vascularization: from Angiogenesis to Microfluidic Blood Vessels. Journal of Cardiovascular Pharmacology and Therapeutics. 2014; 1074248414528576. View PDF
- Miklas JW, Nunes SS, Zhang B, Radisic M. Design and fabrication of biological wires. Cardiac Tissue Engineering: Methods and Protocols. 2014; 157-165. View PDF
- Dang LT, Feric NT, Laschinger C, Chang WY, Zhang B, Wood GA, Stanford WL, Radisic M. Inhibition of apoptosis in human induced pluripotent stem cells during expansion in a defined culture using angiopoietin-1 derived peptide QHREDGS. Biomaterials. 2014; 35 (27), 7786-7799. View PDF
- Xiao Y, Zhang B, Liu H, Miklas JW, Gagliardi M, Pahnke A, Thavandiran N, Sun Y, Simmons C, Keller G, Radisic M. Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle. Lab on a Chip (Cover article). 2014; 14 (5), 869-882. View PDF
- Zhang B, Peticone C, Murthy SK, Radisic M. A standalone perfusion platform for drug testing and target validation in micro-vessel networks. Biomicrofluidics. 2013; 7 (4), 044125. View PDF
- Nunes S, Miklas JW, Liu J, Aschar-Sobbi R, Xiao Y, Zhang B, Jiang J, Massé S, Gagliardi M, Hsieh A, Thavandiran N, Laflamme MA, Nanthakumar K, Gross GJ, Backx PH, Keller G, Radisic M. Biowire: a platform for maturation of human pluripotent stem cell–derived Cardiomyocytes. Nature Methods. 2013; 10 (8), 781-787. View PDF
- "Biowires" highlighted in:
- The Science Daily, "New 'biowire' technology matures human heart by mimicking fetal heartrate", 2013.
- "Biowires" highlighted in:
- Martin C, Sofla A, Zhang B, Nunes S, Radisic M. Fusible core molding for fabrication of branched three-dimensional perfusable microvessels for vascular tissue engineering. International Journal of Artificial Organs. 2013; 36 (3), 159-165. View PDF
- Leng L, McAllister A, Zhang B, Radisic M, Günther A. Mosaic hydrogels: Dynamic tessellation and coding. Advanced Materials (Cover Article), 2013; 24 (27), 3650-3658. View PDF
- Tandon V, Zhang B, Radisic M, Murthy SK. Generation of Tissue Constructs for Cardiovascular Regenerative Medicine: From Cell Procurement to Scaffold Design. Biotechnology Advances, 2013; 31 (5), 722-735. View PDF
- Zhang B, Green J, Murthy S, Radisic M. Label-free enrichment of functional cardiomyocytes using microfluidic deterministic lateral flow displacement. Plos-One. 2012; 7 (5), e37619. View PDF
- Zhang B, Xiao Y, Hsieh A, Thavandiran N, Radisic M. Micro and nanotechnology in cardiovascular tissue engineering. Nanotechnology. 2011; 22 (49), 494003. View PDF
- Hirsch A, Rivet CA, Zhang B, Kemp ML and Lu H. Parallel Multi-time Point Cell Stimulation and Lysis on-chip for Studying Early Signaling Events in T Cell Activation. Lab on a Chip. 2009; 9 (4), 536-544. View PDF